Medical Pharmcology Chapter 27: Gastrointestinal Pharmacology Practice Questions

The enzyme pepsin mediates hydrolysis of mucosal proteins. Consequence(s) of this effect on mucosal proteins include/includes:
1. Development of ulcerations
2. Mucosal erosion
3. Both
4. Neither
Sucralfate (Carafate and others):
1. Composed of sucrose octasulfate to which Al(OH)₃ has been added.
2. Sucralfate in acidic environments (pH <4) undergoes cross-linking reactions that produce a polymeric hearing to both epithelial cells and "ulcer craters."
3. Both
4. Neither
Sucralfate effect(s):
1. Increases local prostaglandin production.
2. Enhances epidermal growth factor.
3. Inhibits pepsin-mediated hydrolysis of mucosal proteins.
4. A & B
5. B & C
6. A & C
7. A, B & C
Biliary esophagitis (should it exist) has been occasionally managed using sucralfate.
1. True
2. False
Concerning sucralfate:
1. Despite the advent of proton pump inhibitors, sucralfate is commonly used.
2. Sucralfate may be more effective in preventing stress ulcers compared to H₂ receptor blockers or proton pump inhibitors.
3. Both
4. Neither
Sucralfate may be helpful in which one(s) of the following?
1. Oral mucositis
2. Bile reflux gastropathy
3. Both
4. Either
Sucralfate may be effective in treating which one(s) of the following conditions?
1. Radiation proctitis
2. Single rectal ulcers
3. Both
4. Neither
Most common side effect associated with sucralfate administration:
1. Shortness of breath
2. Splenomegaly
3. Constipation
4. Excessive diuresis
Antacids containing aluminum should not be used in combination with sucralfate in patients at risk for aluminum overload.
1. True
2. False
Viscous coatings in the stomach due to sucralfate administration may inhibit absorption of which one(s) of the following drugs?
1. Phenytoin
2. Ketoconazole
3. Fluroquinolone antibiotics
4. A & B
5. B & C
6. C only
7. A, B & C

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions