Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Prokinetic drugs:
1. Increase coordinated gastrointestinal motility.
2. Promote transit of material through the G.I. tract.
3. Both
4. Neither
An example of an effective prokinetic agent would be represented by muscarinic receptor agonist or by inhibitors of the enzyme acetylcholinesterase.
1. True
2. False
Potential clinical use(s) of agents selectively stimulating G.I. motor activity (prokinetic drugs):
1. Helpful in managing gastroesophageal reflux disease (GERD)
2. Helpful in enhancing gastric emptying and postoperative ileus or chronic intestinal "pseudo-obstruction."
3. Both
4. Neither
Primary neurotransmitter receptor system constituting the focus for agents with therapeutic potential for improving gastrointestinal applications.
1. Cholinergic
2. Dopaminergic
3. Kinins
4. Serotonergic (5-HT)
Focus of 5-HT drug development for G.I. applications:
1. 5-HT₃ receptor blockers
2. 5-HT₄ receptor agonists
3. Both
4. Neither
Bethanechol, cholinergic agonist, has been previously used for management of GERD and gastroparesis.
1. True
2. False
Intravenous neostigmine:
1. May be used in hospitalized patients with acute bowel distention i.e. Ogilvie's syndrome.
2. Enhances small intestine and colonic emptying
3. Both
4. Neither
Cholinergic effects associated with neostigmine as well as cholinergic agonist generally:
1. Vomiting
2. Bradycardia
3. Diarrhea
4. A & B
5. B & C
6. A & C
7. A, B & C

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions