Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Effect(s) of dopamine in the G.I. tract:
1. Inhibitory effect on motility
2. Reduction of lower esophageal sphincter pressures
3. Elevation of intragastric pressures
4. A & B
5. B & C
6. A & C
7. A, B & C
G.I. effects of dopamine:
1. Secondary to reduced acetylcholine release from myenteric motoneurons.
2. Mediated by D₂ type dopamine receptors.
3. Both
4. Neither
Pharmacological effect(s) of dopamine receptor blockers:
1. Prokinetic drugs
2. Reduced nausea and vomiting
3. Both
4. Neither
Dopamine receptor blocker(s):
1. Metochlopramide (Reglan)
2. Domperidone (Motilium and others)
3. Both
4. Neither
Effect(s) of metochlopramide administration:
1. Coordinated G.I. contractions enhancing G.I. content transit.
2. Most effects center on upper digestive tract.
3. Both
4. Neither
Effect(s) of metochlopramide administration:
1. Stimulation of antral and small intestinal contractions
2. Stimulation of large-bowel motility
3. Both
4. Neither
Characteristic(s) of metochlopramide:
1. Rapid absorption following oral administration
2. Phase II metabolism in the liver (sulfation and glucuronide conjugation)
3. Both
4. Neither
Duration of action of metoclopramide following oral administration:
1. About 20 min.
2. About 1-2 hours
3. About 12 hours
4. One day
Metochlopramide may be appropriate in patients exhibiting gastroparesis.
1. True
2. False
Metoclopramide effect on gastroparesis may result in gastric emptying improvement to a moderate degree.
1. True
2. False

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions