Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Eluxadoline (Reversi):
1. Opiate agonist (mu receptor)
2. Slower colonic transit; increased fecal fluid absorption.
3. Both
4. Neither
Eluxadoline: approved for management of diarrhea-predominant irritable bowel syndrome (IBS).
1. True
2. False
Contraindication(s) for eluxadoline administration:
1. In patients with known sphincter of Oddi disease.
2. In patients with pancreatitis history or alcoholism.
3. Both
4. Neither
Diphenoxylate or difenoxin: CNS activity results in abuse potential or addiction.
1. True
2. False
Diphenoxylate or difenoxin when combined with atropine and given at high doses anticholinergic effects can result in:
1. Nausea
2. Blurred vision
3. Both
4. Either
Opioids used for diarrhea:
1. Codeine
2. Paragoric
3. Both
4. Neither
Enkephalins, endogenous opioids, can be administered to manage acute diarrhea.
1. True
2. False
Enkephalins and management of diarrhea:
1. These agents reduce intestinal secretion without influencing intestinal motility.
2. Racecadotril (acetorphan) is in enkephalin prodrug converted to thiorphan that can produce an antidiarrheal effect.
3. Both
4. Neither
The racecadotril metabolite thiorphan:
1. Increases endogenous enkephalin effects on the mu opioid receptor in the G.I. tract.
2. Antidiarrheal effect is due to anti-secretory properties.
3. Both
4. Neither
Antidiarrheal effects of thiorphan occurs as a result of reducing peripheral enkephalin degradation.
1. True
2. False

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions