Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
Adverse effect(s) associated with octreotide administration:
- Steatorrhea secondary to impaired pancreatic secretion
- Long-term administration of octreotide may cause gallstones (or sludge) in over half of patients.
- Both
- Neither
Octreotide administration can lead to:
- Hyperglycemia
- Hypoglycemia
- Both
- Neither
Extended treatment with octreotide can result in:
- Hypothyroidism
- Tachycardia
- Both
- Neither
Octreotide of somatostatin (SST) are effective in treating acute pancreatitis.
- True
- False
Telotristat ethyl (Xermelo):
- Reduces diarrhea due to carcinoid tumors.
- Mechanism of action involves inhibiting tryptophan hydroxylase which is the rate-limiting enzyme associated with serotonin biosynthesis.
- Both
- Neither
Serotonin secretion (5-HT secretion) induces fluid secretion and enhances motility in the G.I. tract.
- True
- False
Telotristat ethyl:
- Absorbed following oral administration, then converted to the active agent, Telotristat.
- Telotristat Is administered along with somatostatin analogs in treating diarrhea in carcinoid syndrome.
- Both
- Neither
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