Medical Pharmacology Chapter 1: General Principles Practice Quesions

Description of ciprofloxacin include/includes:
1. This drug shows both acidic and basic properties.
2. This drug is classified as a fluroquinolone antibacterial.
3. Ciprofloxacin contains two tertiary alkyl amines, a secondary alkyl amine and a carboxylic acid.
4. Since ciprofloxacin may either accept a proton (at the secondary alkylamine) or donate a proton (carboxylic acid) or both, the drug is described as amphoteric.
5. A & B
6. B & C
7. A, B & C
8. All answers are correct (A-D)
Each functional group in a drug which can either donate or accept a hydrogen bond is important in assessing the drugs overall water solubility.
1. True
2. False
Stereoisomers described drugs which contain the same number and types of atoms with the same bond arrangements and the same three-dimensional structures.
1. True
2. False
Which one/ones of the following statements is/are correct?
1. Most drugs on the market today represent isomeric mixtures.
2. Most drugs which are isomeric mixtures are described as racemic mixtures or "racemates"
3. Both
4. Neither
Which one/ones of the following characteristics represent differences exhibited by individual isomers in racemates?
1. Differences in serum protein binding
2. Significant differences in active transport
3. Differences in drug metabolism
4. A & B
5. B & C
6. A & C
7. A, B & C
Changing the length of an alkyl chain and a drug or changing a ring size and the drug may affect:
1. Drug potency
2. Pharmacological activity
3. Both
4. Neither
A change in the length of an alkyl chain by one CH₂ unit or branch not only changes drug lipophilicity but also may alter which one/ones of the following properties?
1. Drug absorption
2. Drug excretion
3. Drug distribution
4. A & B
5. All of the properties i.e. A & B & C
If alkyl chain is present in the drugand is involved in an important way in drug interaction with the receptor, alteration in the alkyl chain may influence drug efficacy.
1. True
2. False
Some drug candidates are metabolites of existing drugs yet the newer drug (metabolite) may be clinically superior.
1. True
2. False
Typically drugs that block actions of neurotransmitter such as norepinephrine or dopamine i.e. drug antagonists tend to be larger than the native agent.
1. True
2. False