Medical Pharmacology General Principles Practice Questions

Structure activity relationships (SARs) represent the foundational principle of medicinal chemistry.
1. True
2. False
Functional groups within a drug are typically additive to resulting biological actions.
1. True
2. False
Factor/factors important in drug-receptor interactions:
1. Drug ionization states
2. Drug functional group geometries and size
3. 3-D (three-dimensional) orientation
4. A & B
5. B & C
6. C
7. A & C
8. A, B & C
Acid-base characteristics of drug molecules influence/influences:
1. Drug excretion
2. Drug absorption
3. Interaction (compatibility) with other drugs and solution
4. Interaction (compatibility) with other drugs and solution
5. A & B
6. B & C
7. A & C
8. A, B & C
A "base" is a substance capable of yielding a proton (H+).
1. True
2. False
A drug which is considered an acid would be capable of yielding a proton.
1. True
2. False
An acidic functional group of the drug:
1. Upon losing its proton, the functional group might be described as having undergone "dissociation."
2. Following dissociation, the functional group o exhibits an extra electron and would be negatively charged.
3. Such a negatively charged state would be described as the ionized state of the drug (acid).
4. Ionized functional groups are less likely to exhibit ion-dipole interactions with water.
5. A & B
6. B & C
7. A & C
8. A, B & C
9. All of the options are correct (A, B, C & D)
Prediction of acid strengths in drug functional groups may facilitate understanding of which one(s) of the following?
1. Absorption
2. Drug compatibilities
3. Distribution
4. Excretion
5. A & B
6. B & D
7. All of the choices (A, B, C, & D)
When a basic functional group in a drug accepts an additional proton the drug becomes ionized and is therefore:
1. Negatively charged
2. Uncharged
3. Positively charged
This basic functional group is unable to accept a proton.
1. A primary amine
2. A secondary amine
3. A tertiary amine
4. A quaternary amine