Pharmacology General Principles: Practice Questions

At high doses of this drug glucuronidation and sulfation pathways become saturated, resulting in cytochrome P450-dependentpathways becoming more important. Under certain conditions, with depletion of hepatic glutathione, hepatic toxic reactive metabolites may be formed. This drug is:
1. Coumarin
2. Acetaminophen
3. Morphine
4. Diazepam
5. Ketamine
An example of an unsafe drug for use in a patient with acute intermittent porphyria is represented by which agent below?
1. Fentanyl
2. Methohexital
3. Glucocorticoids
4. Atropine
5. Chlorpromazine
The following structure represents which one of the following:
1. Thiopental
2. Methohexital
3. Propofol
4. Midazolam
5. Etomidate
The following structure represents which one of the following?
1. Thiopental
2. Methohexital
3. Propofol
4. Midazolam
5. Etomidate
The following structure represents which one of the following?
1. Morphine
2. Fentanyl
3. Sufentanil
4. Alfentanil
Which one(s) of the following statement(s) is/are correct concerning the pharmacology of fentanyl and related agents?
1. Sufentanil is about six times more potent but with a slower onset of action compared to fentanyl.
2. Alfentanil is an example of a fentanyl derivative that is more potent than the parent compound fentanyl.
3. In terms of ranking with respect to CNS and respiratory depression fentanyl is >sufentanil which is >alfentanil.
4. Alfentanil may induce muscle rigidity which is more notable both in duration and magnitude of effect compared to fentanyl.
5. All of the above statements are correct.
Which statement(s) concerning fentanyl pharmacology is/are correct?
1. Fentanyl is significantly more potent, 100 times relative to morphine.
2. Anesthetic dosage ranges from 30 micrograms/kg to 100 µg/kg.
3. Both
4. Neither
Select the agent most likely to cause positive chromotropism (increased heart rate).
1. Propofol
2. Ketamine
3. Etomidate
4. Alfentanil
5. Morphine
Of the following benzodiazepines used in the anesthetic setting, which one is most frequently used for preoperative sedation or for anesthesia induction?
1. Diazepam
2. Midazolam
3. Lorazepam
4. Clonazepam
Which one of the following drugs is classified as a phencyclidine derivative?
1. Midazolam
2. Etomidate
3. Ketamine
4. Propofol
5. Methohexital
The hydrophobic properties of this agent require it to be formulated in a special phosphatidylcholine (lecithin) emulsion consisting of soybean oil and egg yoke.
1. Propofol
2. Etomidate
3. Alfentanil
4. Ketamine
5. Thiopental
Concerning opioid mechanism of action: opioid agonists tend to decrease potassium ion and increase calcium ion conductance which have the effect of hyperpolarizing the membrane, thus inhibiting neuronal activity.
1. True
2. False
Which one of the following agents is more likely to induce venodilation and histamine release?
1. Morphine
2. Fentanyl
3. Both equally likely
Type(s) Of derivatives associated with phase II metabolic reactions include(s):
1. Glucuronide acid derivatives
2. Sulfation derivatives
3. Both
4. Neither
Example(s) of major plasma proteins important for drug binding:
1. Lipoproteins
2. alpha1-acidic glycoproteins
3. Albumin
4. All of the above