Pharmacology General Principles: Practice Questions

In reference to Fick's law, which one of the following components exhibits and Inverse relationship with respect to flux (J)?
1. Concentration difference
2. Thickness
3. Permeability coefficient
4. All of the above
Plasma protein-bound drugs generally cannot permeate through aqueous pores.
1. True
2. False
Pentobarbital at a pH below its pKa will exhibit relatively:
1. Increased ionization
2. Decreased ionization
Choose the week base(s) from the following agents.
1. Acetaminophen
2. Ephedrine
3. Phenobarbital
4. Pentobarbital
The release of neurotransmitters at the presynaptic terminal is associated with a process that is called:
1. Endocytosis
2. Exocytosis
Example(s) of (an) agent(s) which may be administered by the transdermal route of administration:
1. Clonidine
2. Fentanyl
3. Scopolamine
4. Nitroglycerin
5. All of the above
Which one of the following drugs exhibits a larger volume of distribution?
1. Digoxin
2. Chloroquine
Which one of the following represents the physical volume most closely approximating extracellular water?
1. 0.07 L/kg
2. 0.4 L/kg
3. 0.5-0.7 L/kg
4. 0.2 L/kg
Which one(s) of the following statement(s) correctly describes/describes factors In renal excretion?
1. Renal tubular reabsorption rate will be influenced by the rate of renal tubular urine flow.
2. The higher the fraction of free drug, the slower the excretion since the plasma protein-bound form of the drug is eliminated preferentially.
3. The glomerular filtration rate is usually in an important factor in renal excretion
4. All of the above
The number of half-lives required to move from one steady-state drug level to 94% of another steady-state level is about:
1. One drug half-life
2. Two drug half-lives
3. Three drug half-lives
4. Four drug half-lives
5. Five drug half-lives
Which one(s) of the following statements is/are influence(s) of age on diazepam half-life?
1. Clearance changes with age
2. Volume of distribution does not change with age.
3. Both
4. Neither
Small changes in fraction of drug bound significantly influences free plasma concentration for which one(s) of the following drug(s)?
1. Warfarin
2. Propranolol
3. Phenytoin
4. Diazepam
5. All of the above
Which one of the following agents is significantly metabolized by phase II glucuronidation?
1. Dopamine
2. Coumarin
3. Clonazepam
4. Morphine
5. Ethacrynic acid
Glucuronidation type reactions are principally associated with which one of the following categories of drug metabolizing systems?
1. Phase I
2. Phase II
Characteristic(process) of drug metabolic conjugates usually include(s):
1. Increased biological activity
2. Reduction in ease of excretion
3. Reduced Drug polarity
4. None of the above