Pharmacodynamic Practice Questions

Which one of the following drug receptor classes have been best decribed and characterized?
1. enzymes
2. structural proteins
3. transport proteins
4. regulatory proteins
Which one(s) of the following is an example of a structural protein?
1. Na+/K+-ATPase
2. tubulin
3. dihydrofolate reductase
4. all of the above
Which one of the statements best decribes an "orphan" receptor?
1. A receptor for which the function is unknown.
2. A receptor for which no naturally occuring (endogenous) agent has been identified.
3. A receptor associated with a rare disease?
4. A receptor which is associated with disease but which has not attracted significant research interest?
In a patient, a response to a low dose to a drug is likely followed by an indefinitely increasing response as the dose is increased.
1. true
2. false
A high enough concentration of an agonist drug (causes the biological effect) can prevent the effect of a competitive antagonist (blocking) drug.
1. True
2. False
After a non-competitive drug has bound to its receptor, subsequent administration of an agonist drug is unlikely to reverse the block.
1. True
2. False
This/these drug(s) is/are (an) example(s) of an effectively irreversible alpha-adrenergic receptor blocker.
1. phentolamine
2. phenoxybenzamine
3. both
4. neither
This is a defining characteristic of a partial agonist drug.
1. This type of drug cannot fully occupy the available receptors.
2. This type of drug has a reduced affinity for the receptor compared to full agonists.
3. This type of drug produces a reduced response compared to a full agonist because of a limit on the ability to give enough partial agonist drug.
4. This type of drug, even at doses that fully saturate the receptor, does not elicit a response as great as that seen with a full agonist.
Concerning drug antagonism, "physiological antagonism" involves which one(s) of the following:
1. A case in which one drug acts as an antagonist of another.
2. A case in which the antagonism involves endogenous regulatory pathways mediated by different receptors.
3. both
4. neither
A lipid-soluble drug crossing a membrane to act on an intracellular receptor is an example of a basic mechanism of transmembrane signaling.
1. True
2. False