Pharmacodynamic Practice Questions

Medical Pharmacology: Pharmacodynamics Practice Questions

Choose the correct answer for each question.

Which one(s) of the following drugs work through a specific, discrete mechanism but affect many organ systems?
1. methotrexate
2. digoxin
3. Both
4. Neither
Global systemic effect(s) of furosemide, a diuretic, is/are:
1. skeletal muscle cramps
2. cardiac arrhythmias
3. both
4. neither
Amiodarone, an antiarrhythmic drug, exhibits all of the following properties EXCEPT:
1. inhibition of sodium channels
2. inhibition of calcium channels
3. activation of potassium channels
4. noncompetitive inhibition of beta-adrenergic receptors
Choose the correct statement(s) concerning the anti-arrhythmic drug, sotolol.
1. Sotolol as administered contains both an l- and a d- enantiomer.
2. The l-enantiomer of sotolol is a potassium channel blocker whereas the d-enantionmer is not.
3. The l-enantiomer is a much more potent beta-adrenergic receptor blocker compared to the d- form
Chronic drug adminstration can results in which one(s) of the following effects?
1. down-regulation of receptor number
2. receptor desensitization
3. tachyphylaxis
4. all of the above effects can occur with chronic administration of certain drugs.
Which one(s) of the follow characteristics may be responsible for pharmacodynamic variability in population response to a drug?
1. disease
2. age
3. co-administrated drugs
4. genertics
Definition of the "therapeutic index."
1. ED50/LD50
2. ED50
3. ED50/population age
4. ED50/therapeutic window
Variation in an individual's response to a drug may be due to various factors. Which one(s) of the following factors may influence a patient's response to a drug?
1. Reduced drug clearance by the kidneys
2. Reduced drug clearance due to hepatic disease
3. Circulatory failure
4. Gastrointestinal absorption impairment
5. Pharmacokinetic drug-drug interaction.
Inter-individual sensitivity to genetic factors influencing warfarin's pharmacokinetics and pharmacodynamic is mainly due to which one(s) of the following?
1. Variability of drug receptor sensitivity.
2. Variation in the principal drug metabolizing enzyme (CYP2CP, a cytochrome p450 isofom).
3. Both
4. Neither
Co-administration of nitroglycerin and sildenfil can result in a profound, very serious hypotensive reaction>
1. True
2. False

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