Pharmacodynamic Practice Questions

Which one(s) of the following drugs act by either enhancing or reducing neurotransmitter effects?
1. cocaine
2. alpha-methyltyrosine
3. amphetamine
4. A & C only are correct
5. A, B & C answers are correct.
Which one(s) of the following drugs act by interacting with ion pumps and transporters in nephron epithelial cells?
1. Furosemide
2. Amiloride
3. Mannitol
4. Amiloride
Functional domains within receptors involved in modifying activity of cellular pathways include:
1. Ligand-binding region
2. Effector region
3. Both
4. Neither
Which one(s) of the following statements are correct concerning drugs affecting signal transduction pathways?
1. Cetuximab (monoclonal antibody) interacts with the ligand binding site of the epidermal growth factor receptor.
2. Gefinib binds to the extracellular effector domain.
3. Erlotinib binds to the extracellular effector domain
4. All of the above statements are correct.
Concerning signal integration and amplification, choose the correct statement (s).
1. In cardiac myocytes, increasing cellular cAMP due to beta-adrenergic receptor activation results in a negative inotropic effect (reduced contractility).
2. In smooth muscle cells, calcium ions enhance contractiliy while beta-adrenergic receptor activation causes smooth muscle relaxation.
3. Both A and B are correct.
4. Neither A or B is correct.
Prostaglandins, leukotrienes and thromboxanes are associated with which one of the following functional receptor families?
1. Muscarinic cholinergic receptors
2. Eicosainoid receptors
3. Cytokine receptors
4. Steroid receptors
The soluble guanylyl cyclase functional family is associated with with one(s) of the following ligands?
1. Nitric oxide (NO)
2. calcium ions
3. Both
4. Neither
This drug mainly works through the beta adrenergic receptor structural family.
1. misoprostol
2. neseridtide
3. dobutamine
4. herceptin
Which one(s) of the following statements concerning G protein Coupled Receptors (GCPRs) is/are correct?
1. GPCRs extend through the plasma membrane as seven alpha helical protein structures.
2. GCPRs represent the third largest family of genes in humans.
3. A ligand for GPCRs include both acetylcholine and norepinephine, among others.
4. All of the above
Alpha 1, alpha 2 and beta adrenergic receptors differ from each other in terms of ligand selectivity and G protein coupling.
1. True
2. False