Medical Pharmacology: Pharmacodynamics Practice Questions
Choose the correct answer for each question.
Pharmacodynamics describes both drug effects and mechanisms of action.
True
False
Drug receptors by contrast to drug "acceptors" do not change physiological and biochemical responses but are more likely to change pharmacokinetics describing a drug's actions.
True
False
Example/examples of more recently introduced drugs have been described as "therapeutic biologics" and include/includes:
Monoclonal antibodies
Engineered enzymes i.e. by genetic manipulation for example
Both
Neither
Examples of a new generation of pharmacological agents allow directed genome editing, taking advantage of RNAi, antisense oligonucleotides, and CHRISPR/Cas9 technology
True
False
Characteristic/characteristics of many drug receptors:
These drug receptors are usually proteins and interact with endogenous, small molecules which serve regulatory functions
These drug receptors are described as "physiological receptors."
Both
Neither
Drugs which bind to the same specific receptor site as the endogenous (normally found in the body) ligand and exert the same regulatory effects typically describes/describe:
Agonist
Antagonist
Both
Neither
Mechanism/mechanisms of drug antagonists:
Chemical antagonism
Functional antagonism
Both
Neither
Usually drug antagonism involves an antagonist interacting in a competitive way with the agonist for either the same or at an overlapping receptor site. This type of antagonism is described as a "syntopic interaction."
True
False
Partial agonists, as the name suggests, our agonists that activate the receptor to a degree less than the full agonist.
True
False
Concerning "inverse agonists":
These agents stabilize receptors in an inactive conformation
Inverse agonists, as well as partial agonists, appear as competitive antagonists in the presence of a full agonist.
