Medical Pharmacology Chapter 3: Pharmacodynamics Practice Questions

Which one(s) of the following statements about receptors is/are correct?
1. Selectivity of drug action depends on receptors.
2. Drugs classified as antagonists or agonists mediate their effects their receptors.
3. Dose-response drug characteristics are mediated by receptors.
4. A & B
5. B & C
6. A & C
7. A, B & C
The drug-receptor dissociation or affinity constant represents a measure of the tendency of drug-receptor binding.
1. True
2. False
Drug stereoisomers may exhibit:
1. Different pharmacokinetic properties
2. Different pharmacodynamic properties
3. Both
4. Neither
Concerning the antiarrhythmic drug sotalol: which one/ones of the following statements is/are correct?
1. Sotalol, as prescribed, is a racemate with equal amounts of the D-and L-enantiomers.
2. Sotalol enantiomers are equal potent with respect to potassium channel blockade.
3. The L-sotalol enantiomer is substantially more potent compared to the D-enantiomer with respect to ß adrenergic receptor blockade.
4. A & B
5. B & C
6. A & C
7. A, B & C
Rapid development of complete tolerance to a drug's effect, such as seen with repetitive or chronic administration of nitrate vasodilators for management of angina is an example of tachyphalaxis.
1. True
2. False
Possible consequences of chronic drug administration:
1. Response desensitization
2. Receptor down-regulation
3. Both
4. Neither
The pharmacological action of this agent is not mediated by a "macromolecular" receptor molecule.
1. Propranolol
2. Mannitol
3. Prazosin
4. Atenolol
Varenicline (Chantix) is an example of a partial agonist at the nicotinic receptor.
1. True
2. False
At sufficiently high concentrations, a partial agonist him he can achieve the same, maximal effect of a full agonist.
1. True
2. False
If the same concentration of the drug is administered to a population of individuals, each individual will exhibit the same magnitude of pharmacological response.
1. True
2. False