Medical Pharmacology Chapter 3: Pharmacodynamics Practice Questions

Membrane transporter(s) effect/effects:
1. These systems often play an important role in drug distribution and metabolism.
2. Membrane transporters are important in determining systemic drug concentrations.
3. Both
4. Neither
Concerning ABC proteins (ATP-binding cassette proteins):
1. Major active transporter class.
2. Dependent on ATP binding but not ATP hydrolysis.
3. Both
4. Neither
The ABC superfamily of proteins (ATP-binding cassette transporter proteins) includes the PGP protein (P-glycoprotein).
1. True
2. False
PgP (P-glycoprotein) is coded for by the MDR1 a.k.a. ABCB1 gene.
1. True
2. False
Principal activity/activities of the SLC gene superfamily (solute carrier superfamily) of membrane transport proteins:
1. Facilitated transport
2. Ion-coupled secondary active transporters
3. Both
4. Neither
Example/examples of the SLC transporter(s):
1. SERT
2. DAT
3. Both
4. Neither
Liver drug transporters: choose the correct statement/statements.
1. Intrahepatocyte hepatic drug transporters are important for phase 1 but not phase 2 drug-metabolizing systems.
2. Hepatic drug transporters facilitate both uptake and drug efflux, including transport of drug metabolites
3. Both
4. Neither
Concerning the drug tetrabenazine (Xenazine),
1. Xenazine (tetrabenazine) may be helpful in reducing some symptoms of Huntington's disease.
2. Xenazine (tetrabenazine) exhibits antichorea activity in Huntington's disease
3. Both
4. Neither
Examples of SLC5 family drugs useful for treating type II diabetes:
1. Dapagliflozin (Farxiga)
2. Canagliflozin (Invokana)
3. Empagliflozin (Jardiance)
4. All of the above
This agent has been approved for patients with cystic fibrosis exhibiting a particular coding mutation.
1. Ivacaftor (Kalydeco)
2. Empagliflozin (Jardiance)
3. Both
4. Neither