Medical Pharmacology Practice Questions: Anti-Histamine Pharmacology

H2-histamine receptor antagonists were effective in managing acid-peptic disease because H2 receptor blockers inhibited the proton pump.
1. True
2. False
Site of action for H2 receptor antagonists with respect to acid production inhibition:
1. Parietal cells
2. Chromaffin cells
3. Mast cells
Choose the correct statement(s) concerning H2 receptor antagonists:
1. H2 receptor antagonists typically suppress gastric secretion for about four hours.
2. H2 receptor blockers tend to inhibit gastric secretion by about 25%.
3. Both
4. Neither
Which one(s) of the following agents are classified as H2 histamine receptor antagonists?
1. Chlorpheniramine
2. Ranitidine
3. Both
4. Neither
Which one(s) is/are (an) example(s) of (an) H2 histamine receptor antagonist(s)?
1. Cimetidine
2. Ranitidine
3. Both
4. Neither
Choose the most potent H2-histamine receptor antagonists compared to cimetidine (least potent):
1. Ranitidine
2. Nizatidine
3. Famotidine
Cimetidine, famotidine, and ranitidine undergo first pass, liver metabolism parent drug enters the systemic circulation.
1. True
2. False
The bioavailability of ranitidine is estimated at about 50% of the oral dose..
1. True
2. False
This age to-histamine receptor blocker, compared to the others listed, exhibit minimal first-pass hepatic metabolism.
1. Nizatidine
2. Cimetidine
3. Ranitidine
4. Amantidine
H2-histamine antagonists dosing may require reduction in patients exhibiting either renal (moderate to severe) or liver (severe) insufficiency.
1. True
2. False