Medical Pharmacology Chapter 25: Pulmonary Pharmacology Practice Questions

Bronchodilator drug classification groups which reverse asthma induced airway obstruction:
1. Theophylline
2. ß₂ adrenergic agonists
3. Cholinergic agonists
4. A & B
5. B & C
6. A & C
7. A, B & C
Direct-acting bronchodilator characteristics:
1. Cromolyn sodium
2. Corticosteroids
3. Both
4. Neither
Bronchodilator drug group (inhaled route of administration) considered treatment of choice for asthma.
1. Antimuscarinic drugs
2. ß₂ adrenergic receptor agonists
3. Theophylline-like drugs
Characteristic(s) of inhaled ß₂ adrenergic receptor agonists that form(s) the basis of treatment of choice designation:
1. Limited side effects
2. Most effective bronchodilators
3. Both
4. Neither
Nonselective ß agonists which are short acting (e.g. isoproterenol or metaproterenol) are good first-choice alternative to inhaled ß₂ adrenergic agonists.
1. True
2. False
Choose (the) correct statement/statements concerning the use in managing asthma of ß₂ adrenergic receptor agonists:
1. These agonists activate a G protein second messenger system resulting in phosphorylations which promote bronchial smooth muscle relaxation.
2. Administration of these agents may also induce bronchodilation by indirect pathways such as by decreasing bronchoconstrictor mediator release from inflammatory cells.
3. Both
4. Neither
Possible indirect mechanism(s) accounting for ß2 agonist bronchodilation:
1. Limiting or preventing microvascular leakage and thus bronchial mucosal edema caused by histamine or prostaglandin D2
2. Increasing submucosal gland mucus secretion anion transport across airway epithelial cells.
3. Inhibiting cholinergic nerve neurotransmission in the human airway..
4. Reduction or prevention of mediator release from lung mast cells
5. A & B
6. B & C
7. A & C
8. A, B & C
9. A, B, C & D (all responses are correct)
Most effective bronchodilators in management of asthma:
1. Short acting ß₂ agonists
2. Long-acting ß₂ agonists
Short-acting ß₂ adrenergic receptor agonist appear effective against this/these asthma triggers:
1. Cold air
2. Allergens
3. Exercise
4. A & B
5. B & C
6. A, B & C
Example/examples of short-acting ß₂ adrenergic receptor agonist(s) found in clinical use:
1. Albuterol
2. Terbutaline
3. Both
4. Neither