Medical Pharmacology: Pulmonary Pharmacology Practice Questions
Choose the correct answer for each question.
Leukotriene pathway inhibitor acting by enzyme inhibition:
Montelukast
Zileuton
Zafirlukast
For inducing and as maintenancein management of asthma leukotriene pathways inhibitors appear at least as effective for more effective than inhaled corticosteroid treatment.
True
False
Possible advantage/advantages of leukotriene pathway inhibitors compared to inhaled corticosteroids in management of asthma in children
Sometimes parents prefer leukotriene pathway inhibitors (zileuton,zafirlukast, montelukast) compared to inhale steroids due to concerns about corticosteroid toxicities.
Oral administration of leukotriene pathway inhibitors may be better tolerated i.e. easier then young children's acceptance of aerosol inhalation.
Both
Neither
The leukotriene receptor blocker montelukast has been approved in children as young as one year of age.
True
False
Particularly effective role for leukotriene pathway inhibitors:aspirin-worsened respiratory disease (about 7% of asthma patients.)
True
False
Characteristics of aspirin-exacerbated respiratory disease (AERD):
Asthma features
Rhinosinusitis with nasal polyps
Both
Neither
AERD (aspirin-exacerbated respiratory disease) is likely due to prostaglandin synthase (cyclooxygenase) inhibition.
True
False
Most often prescribed of the leukotriene pathway inhibitors:
Zileuton
Montelukast
Zafirlukast
Anti-leukotriene medications:
Effective in preventing exercise-induced asthma
Principal mechanism of action is anti-bronchoconstriction
Both
Neither
Zafirlukast, zileuton and montelukast:
Associated with hepatic dysfunction (rare)
Zafirlukast and montelukast may be associated with Churg-Strauss syndrome.
