Medical Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Agent(s) used to treat central diabetes insipidus.
1. Vasopressin (Vasostrict)
2. Desmopressin (DDAVP)
3. Both
4. Neither
Renal effects of vasopressin and desmopressin mediated by V₂ ADH receptors.
1. True
2. False
Cause(s) of diabetes insipidus:
1. Inadequate hypothalamic arginine vasopressin (AVP, ADH) production
2. Impairment of arginine vasopressin (AVP, ADH, Vasopressin) renal activity
3. Both
4. Neither
AVP (ADH) deficiency would be typically associated with excessive dilute urine production.
1. True
2. False
Cause/causes of central diabetes insipidus (inadequate AVP (ADH, Vasopressin) release by physiological stimulus).
1. Neoplasm affecting hypothalamus/posterior pituitary
2. Inflammation of the hypothalamus/posterior pituitary.
3. Idiopathic cause
4. A & B
5. B & C
6. A & C
7. A, B & C
Nephrogenic diabetes insipidus: due to renal arginine vasopressin (AVP, ADH) resistance.
1. True
2. False
Symptom/symptoms associated with diabetes insipidus:
1. Polydipsia
2. Excessive thirst
3. Polyuria
4. A & B
5. B & C
6. A & C
7. A, B & C
This/these agents interfere with antidiuretic hormone (ADH, AVP) biological activity
1. Demeclocycline (Declomycin and others)
2. Lithium
3. Both
4. Neither
A number of ADH receptor antagonists (vaptans) are replacing demeclocycline as agents of choice.
1. True
2. False
ADH receptor antagonists:
1. Conivaptan (Vaprisol)
2. Tolvaptan (Samsca)
3. Both
4. Neither