Medical Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Clinical use(s) of amiloride:
1. Management of lithium-induced nephrogenic diabetes insipidus..
2. Improvement of cystic fibrosis symptoms due to enhanced mucociliary clearance.
3. Both
4. Neither
Most serious (dangerous) adverse effect of "K⁺-sparing diuretics", i.e. renal Na⁺ channel blockers is hyperkalemia.
1. True
2. False
Circumstance(s) in which triamterene and amiloride would likely be contraindicated:
1. Patients receiving angiotensin-converting enzyme inhibitors.
2. Patients with renal failure
3. Both
4. Neither
Contraindication(s) of amiloride or triamterene administration:
1. Hyperkalemic patients
2. Patients receiving K⁺supplementation
3. Both
4. Neither
K⁺ electrolyte monitoring is essential for patients receiving agent such as triamterene or amiloride:
1. True
2. False
Megaloblastosis and cirrhotic patients:
1. In this setting megaloblastosis is likely secondary to folic acid deficiency.
2. Triamterene is a week folic acid blocker, thus increasing the possibility of this adverse effect (megaloblastosis)
3. Both
4. Neither
Adverse effect(s associated with triamterene:
1. Renal stones
2. Interstitial nephritis
3. Reduced glucose tolerance
4. A & B
5. B & C
6. A & C
7. A, B & C
Most common adverse effects due to amiloride administration include:
1. Headache
2. Diarrhea
3. Nausea and vomiting
4. A & B
5. B & C
6. A & C
7. A, B & C
Most common adverse effects due to triamterene include:
1. Dizziness
2. Nausea and vomiting
3. Leg cramps
4. A & B
5. B & C
6. A & C
7. A, B & C
Mineralocorticoids antagonists may be useful in reducing K⁺ (and H⁺) excretion due to blockade of specific mineralocorticoids receptors.
1. True
2. False