Medical Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Renal tubule localization(s) of endothelial cells expressing high aldosterone affinity cytosolic mineralocorticoid receptors.
1. Collecting duct (epithelial cells)
2. Late distal tubule (epithelial cells)
3. Both
4. Neither
Aldosterone-mineralocorticoids receptor complex induces in the nucleus aldosterone-itis proteins (AIPs)
1. True
2. False
This/these agents inhibit aldosterone binding to mineralocorticoid receptors.
1. Eplerenone
2. Spirolactone
3. Both
4. Neither
Concerning pharmacological effect/effects a mineralocorticoid receptor blockers:
1. Urinary excretion effects similar to those caused by epithelial sodium channel inhibitors.
2. Clinical effectiveness of mineralocorticoid receptor blockers is dependent on endogenous aldosterone concentrations.
3. Both
4. Neither
Side effects/effects associated with spirolactone administration include(s):
1. Impotence
2. Menstrual irregularity
3. Gynecomastia
4. A & B
5. B & C
6. A & C
7. A, B & C
Mineralocorticoids blockers are often combined with loop diuretics are thiazides in management of high blood pressure and in treating edema.
1. True
2. False
Use/uses of mineralocorticoids blockers:
1. Treating resistant hypertension secondary to primary hyperaldosteronism
2. Managing refractory edema due to secondary aldosteronism.
3. Both
4. Neither
In some patients early treatment with mineralocorticoid blockers decrease mortality following myocardial infarction with systolic dysfunction.
1. True
2. False
Principal risk associated with mineralocorticoids receptor blockers: hyperkalemia
1. True
2. False
Adverse effect(s) associated with spirolactone administration:
1. Peptic ulcer
2. Gastritis
3. Both
4. Neither