Medical Pharmacology Chapter 22: Serotonin Pharmacology Practice Questions

Concerning serotonin and the respiratory system: For patients with carcinoid syndrome, tumor secretion of serotonin may contribute to episodic bronchoconstriction.
1. True
2. False
Serotonin receptor antagonists (5-HT3):
1. Effective in treating various G.I. problems.
2. Very effective in management of nausea.
3. Both
4. Neither
"Licensed" for treating treating irritable bowel syndrome:
1. Granisetron (Sancuso; Sustol)
2. Alosetron (Lotronex)
3. Cilansetron (Calmactin)
4. A & B
5. B & C
6. A & C
CNS serotonin is importantly involved in sleep-wake cycle control.
1. True
2. False
Site/sites of CNS serotonin release:
1. Synaptic endings
2. Axonal varicosities not associated with specific synapses.
3. Both
4. Neither
Serotonin's effect in acute inflammatory responses it is to increase inflammation (pro-inflammatory) by means of 5-HT2A serotonin subtype receptor activation.
1. True
2. False
Serotonin: appetite and obesity: Serotonin appears to reduce food consumption and favor satiety.
1. True
2. False
Lorcaserin (Belviq):
1. Serotonin receptor agonist
2. Approved for weight loss
3. Both
4. Neither
Concerning serotonin and migraine headaches:
1. Serotonin receptor antagonists are important in acute management of migraine headaches.
2. The triptans e.g. almotriptan or sumatriptan are important, effective antimigraine drugs in the acute setting.
3. Both
4. Neither
The tryptophan category of medications are effective in reducing nausea and vomiting associated with migraine.
1. True
2. False