Medical Pharmacology Chapter 22: Serotonin Pharmacology Practice Questions

Which one(s) of the following statements is/are correct, concerning serotonin pharmacology?
1. Serotonin effects on gastrointestinal smooth muscle include promoting peristalsis along with an increase in tone.
2. Actions of serotonin on the G.I. tract involves only direct action of serotonin on 5H₂ smooth muscle receptors.
3. Both
4. Neither
Consequence(s) of 5-HT₄receptor activation by serotonin in the enteric nervous system:
1. Enhanced acetylcholine release
2. A prokinetic (motility-enhancing) effect confired on selective serotonin agonists (cisapride , Propulsid).
3. Both
4. Neither
Diarrhea (severe) is one consequence of serotonin overproduction with carcinoid tumor. Other substances are likely also involved.
1. True
2. False
Serotonin significantly increases gastrointestinal secretions and as a result induces an emetic effect.
1. True
2. False
Combination of serotonin agonists (particularly selective serotonin reuptake inhibitor agents) along with MAO inhibitors may induce serotonin syndromecharacterized in part by skeletal muscle contractions.
1. True
2. False
High fevers (hyperthermia) associated with serotonin syndrome is one consequence of excessive muscle contraction.
1. True
2. False
Serotonin syndrome as well as malignant hyperthermia a be partially managed by administration dantroline.
1. True
2. False
Although serotonin is not clinically useful, the 5-HT_1A agonist buspirone (BuSpar) can be used to manage anxiety.
1. True
2. False
Example/examples of single-agent drugs approved (USA) for management of obesity.
1. Orlistat (Xenical)
2. Lorcaserin (Belviq)
3. Liraglutide (Victoza; Saxenda)
4. Phentermine (Adipex-P; Lomaira)
5. A & B
6. B & C
7. A & C
8. A, B & C
9. All of the drug options are correct (A, B, C, & D)
The "triptans", 5-HT_1D/1B receptor subtype agonists are used nearly solely for management of migraine headaches.
1. True
2. False