Medical Pharmacology Chapter 22: Serotonin Pharmacology Practice Questions

Concerning migraine headaches:
1. Migraine headaches are found in about 35% of population
2. Aura associated with migraine may begin up to 24 hours prior to pain onset.
3. Effectiveness of antimigraine drugs is dependent on whether aura is present, headache duration, severity and intensity of symptoms as well as genetic factors.
4. A & B
5. B & C
6. A & C
7. A, B & C
Migraine headache involve/involves:
1. Vascular aspects
2. Neural aspects
3. Both
4. Neither
Different phases of a migraine attack are associated with various plasma and platelet serotonin concentrations.
1. True
2. False
Serotonin (5-HT) receptor agonists are useful in managing both acute and chronic management of migraine headaches
1. True
2. False
Pharmacological approaches aimed at preventing migraines utilize/utilizes:
1. Serotonin agonists
2. ß-adrenergic receptor antagonists
3. Certain newer epileptic agents
4. A & B
5. B & C
6. A & C
7. A, B & C
Migraine attacks appear to involve trigeminal nerve effects on intracranial arteries.
1. True
2. False
Sumatriptan and related agents represent first line approaches for treating acute, severe migraine in all patients.
1. True
2. False
Pharmacological target site(s) for sumatriptan (and other triptans)
1. 5-HT_1D receptors
2. 5-HT_1B receptors
3. Both
4. Either
Activation of 5-HT_1D and 5-HT_1Breceptors, localized and meningeal and cerebral vessels resulted in:
1. Vasorelaxation
2. Vasoconstriction
An advantage of the use of triptans in treating acute migraine is that the duration of drug effect is typically longer than the duration of the headache.
1. True
2. False