Medical Pharmacology: Thyroid Pharmacology Practice Questions

Medical Pharmacology: Thyroid Pharmacology Practice Questions

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- Mikael Häggström.When using this image in external works, it may be cited as:Häggström, Mikael (2014). "Medical gallery of Mikael Häggström 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.008. ISSN 2002-4436. Public Domain.orBy Mikael Häggström, used with permission., CC0, via Wikimedia Commons
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Click on the correct answer.

Most common thyroid function disorder:
1. Hypothyroidism (myxedema)
2. Hyperthyroidism
Hypothyroidism:
1. Generally (worldwide), iodine deficiency represents a common cause of hypothyroidism.
2. With sufficient iodine, most cases are caused by Hashimoto's thyroiditis.
3. Both
4. Neither
Hashimoto's thyroiditis:
1. Antibodies against thyroid peroxidase.
2. Occasionally antibodies against thyroglobulin.
3. Both
4. Neither
Hypothyroidism:
1. Typically "primary hypothyroidism"
2. Less frequently "central hypothyroidism" as result of pituitary failure with reduced thyroid stimulation by TSH.
3. Both
4. Neither
Hypothyroidism:
1. Secondary hypothyroidism: reduced pituitary function leading to decreased TSH simulation of the thyroid.
2. Tertiary hypothyroidism: hypothalamic failure.
3. Both
4. Neither
Congenital hypothyroidism: significant preventable cause of "intellectual disability" globally.
1. True
2. False
Goiter:
1. Primary hypothyroidism
2. Secondary hypothyroidism
3. Tertiary hypothyroidism
4. All of the above associated with goiter development.
Thyroid gland regulation of iodine uptake and thyroid hormone synthesis:
1. By intrathyroidal mechanisms independent of TSH.
2. Intrathyroidal mechanisms related to blood iodine levels.
3. Both
4. Neither
Likely to activate the anterior pituitary, promoting TSH release.
1. Dopamine
2. Corticoids
3. Somatostatin
4. TRH
5. A & B
6. B & C
7. A & C
8. A, B & C
Least likely to activate the hypothalamic-pituitary-thyroid axis:
1. Acute psychosis
2. Severe stress
3. Cold
4. Circadian/pulsatile rhythms
5. A & B
6. B & C

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Source Material:
- Koenig RJ Brent GA Chapter 47 Thyroid and Antithyroid Drugs In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC (2023).
- Jameson JL Mandel SJ Weetman AP Ch 383 Hypothyroidism in Harrison's Principles of Internal Medicine, 21e McGraw Hill 2022.
- Jameson JL Mandel SJ Weetman AP Ch 384 Hyperthyroidism and Other Causes of Thyrotoxicosis in Harrison's Principles of Internal Medicine, 21e 2022.
- Jameson JL Mandel SJ Weetman AP Ch 385 Thyroid Nodular Disease and Thyroid Cancer in Harrison's Principles of Internal Medicine, 21e 2022.
- Bong BJ Thyroid Drugs & Anti-thyroid Drugs Ch 38 in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.
- Jonklaas J Cooper DS Ch 213 Thyroid in Goldman-Cecil Medicine E-Book (Goldman L Schafer AI, eds) 26e Elsevier 2020.
- Ritter JM Flower R Henderson G Loke YK MacEwan D Robinson E Fullerton J Chapter 53 Antiviral Drugs Rand & Dale's Pharmacology 10e Elsevier 2024.
- Hollenberg A Chin WW Pharmacology of the Thyroid Gland Chapter 28 in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017.