Medical Pharmacology: Thyroid Pharmacology Practice Questions

Prototype thionamide:
1. Propylthiouracil
2. Methimazole
3. Both
4. Neither
This agent inhibits both thyroid peroxidase and peripheral T₄ to T₃ conversion:
1. Methimazole
2. Propylthiouracil
Most frequent adverse side effect of propylthiouracil and methimazole:
1. Slight tachycardia
2. Puritic rash
3. Hypotension
4. Peripheral vascular disorders
Methimazole and propylthiouracil administration may lead to hypoprothrombinemia with increased bleeding risk.
1. True
2. False
Serious but infrequently encountered adverse effects following propylthiouracil and methimazole administration:
1. Agranulocytosis
2. Hepatotoxicity
3. Both
4. Neither
Vasculitis although uncommon may be a complication encountered with propylthiouracil and methimazole.
1. True
2. False
The likelihood of serious adverse effects is less with methimazole compared to propylthiouracil.
1. True
2. False
Methimazole, because of reduced likelihood of adverse effects, is usually selected clinically instead of propylthiouracil except in cases of:
1. Pregnancy
2. Thyroid storm
3. Both
4. Neither
Thionamides administration, are considered usually effective at controlling hyperthyroidism and patients receiving these agents go into remission within six months to a year.
1. True
2. False
Alternative/alternative for hyperthyroid patients who do not respond to thioamide drugs:
1. Thyroid gland removal by surgery
2. Treatment with radioactive iodine
3. Both
4. Neither