Medical Pharmacology Chapter 24: Vasoactive Peptides

Which one(s) of the following statement/statements is/are correct?
1. Renin is an enzyme.
2. Renin is formed from an inactive precursor, prorenin
3. Both
4. Neither
Principal site of renin synthesis:
1. Heart
2. Lung
3. Renal afferent arterial
4. Ascending loop of Henley
Since human plasma contains 2-5 times more prorenin and than renin, about half of renin surfactant is actually due to prorenin.
1. True
2. False
Stimulus/stimuli for renin secretion include(s):
1. Activation of renin-secreting cells by ß-1 adrenergic receptor activation secondary to increased sympathetic nervous system activity.
2. Reduced sodium chloride transport at the thick ascending limb of the loop of Henle (distal) where it meets the corresponding afferent arterial (macula densa).
3. Decrease pressure or stretch at adrenal afferent arterioles (baroreceptor systems)
4. A & B
5. B & C
6. A & C
7. A, B & C
Factor/factors which inhibit renin secretion:
1. Increased renal afferent arterial stretch
2. ß1--receptor antagonism
3. Both
4. Neither
Renal secretion is enhanced due to increased sodium chloride transport in the ascending limb of the loop of Henle.
1. True
2. False
Concerning angiotensin II: choose the correct answer/answers:
1. Angiotensin II inhibits renin secretion by activating angiontensin II type 1 receptors (localized on juxtaglomerular cells)
2. Renin secretion increases if angiotensin-converting enzyme (ACE) is inhibited.
3. Both
4. Neither
Angiotensinogen is acted upon by renin promoting formation of an active vasopressin of agent, angiotensin I.
1. True
2. False
Primary location of the enzyme responsible for catalyzing conversion of angiotensin I to the active agent, angiontensin II.
1. Liver
2. G.I. tract
3. Pulmonary circulation
4. Adrenal glands
Angiotensin-converting enzyme (ACE) catalyzes inactivation of the vasodilator bradykinin.
1. True
2. False