Medical Pharmacology Chapter 24: Vasoactive Peptide Practice Questions

Activation of prorenin:
1. Proteolytic (mediated by proconvertase 1 or cathepsin B enzymes)
2. Non-proteolytically (upon binding to the pro-renin receptor, PRR)
3. Both
4. Neither
Renin is secreted by juxtaglomerular apparatus granular cells.
1. True
2. False
Pathway(s) involved in regulation of renin secretion:
1. Intrarenal baroreceptor pathway
2. ß1 adrenergic receptor pathway
3. Macula densa pathway
4. A & B
5. B & C
6. A & C
7. A, B & C
Adenosine, prostaglandins, and ATP are involved in regulation of the macula densa pathway which provides an important aspect of salt and water regulation by the renin-angiotensin system.
1. True
2. False
Macula densa pathway: adenosine inhibits renin release when sodium chloride transport increases.
1. True
2. False
The major rate determining factor of angiontensin II synthesis is renin.
1. True
2. False
Factor(s) involved affecting renin release:
1. Dietary salt intake
2. Arterial blood pressure
3. Both
4. Neither
Drug actions influencing renin release:
1. Furosemide increases renin release and plasma renin levels.
2. Nonsteroidal anti-inflammatory drug administration results in reduced renin release
3. Both
4. Neither
Slow conversion of angiotensin I to angiontensin II is characteristic with conversion in plasma.
1. True
2. False
Concerning the ACE gene:
1. Large phenotypic variance in serum ACE levels is due to ACE gene polymorphism
2. The deletion allele in deletion polymorphism causes higher serum ACE levels along with increased bradykinin metabolism
3. Both
4. Neither