Medical Pharmacology Chapter 24: Vasoactive Peptides
Renin catalyzed conversion of angiotensinogen to angiotensin I
Conversion of angiotensin I to angiotensin II by converting enzyme
Degradation of angiotensin II by peptidases
Aspartyl protease (catalyzes the conversion of angiotensinogen to angiotensin I (decapeptide)
Preprohormone is conveted to prohormone which is converted to renin, a glycoprotein.
Most circulatory renin is synthesized in the kidneys
Nephron synthetic and storage site: juxtaglomerular apparatus
Afferent and efferent arterioles contain granular cells; juxtaglomerular cells are a synthetic, storage, and renin release site.
Macula densa: specialized tubular segment: associated with juxtaglomerular vascular elements
Afferent and efferent arterioles and macula densa are innervated by the adrenergic system.
Reid, I.A., Vasoactive Peptides, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 287-303.