Surgical Prophylaxis: Antimicrobial use
Overview --Choice of agents (principles)
need not eradicate every potential pathogen
Effective agent example -- cefazolin (Ancef, Defzol)
long serum half-life
Methicillin (Staphcillin)-resistant Staphylococcus aureus or methicillin (Staphcillin)-resistant coagulase-negative staphylococci -- vancomycin (Vancocin)
routine use of vancomycin (Vancocin) for prophylaxis-- discouraged since it promotes vancomycin (Vancocin)-resistant strains
Colorectal surgery and appendectomy: cefoxitin (Mefoxin) or cefotetan (Cefotan) preferred due to enhanced activity relative to cefazolin (Ancef, Defzol) against anaerobes (bowel), e.g. Bacteriodes fragilis
Agents not recommended
Third-generation cephalosporins (cefotaxime (Claforan), ceftriaxone (Rocephin), cefoperazone (Cefobid), ceftazidime (Fortax, Taxidime, Tazicef), or ceftizoxime (Cefizox)
Fourth-generation cephalosporins: e.g. cefepime (Maxipime)
Rationale:
expense, some are less activin cefazolin (Ancef, Defzol) (against staphylococci)
non-optimal spectrum of action (includes activity against organisms not commonly encountered in elected surgery
widespread for prophylaxis encourages emergence of resistance
Prosthetic valve, coronary bypass, other open-heart procedures, pacemaker/defibrillator implantation
Probable pathogen: -- Staphylococcus epidermidis, Staphylococcus aureus,Corynebacterium, enteric gram-negative bacilli
Antibacterial drug:
cefazolin (Ancef, Defzol), cefuroxime (Zinacef, Ceftin)-- IV
Vancomycin, IV(Vancocin) (if above agents are ineffective or contraindicated)
Antibacterial drug pre-treatment reduces infection incidence after cardiac surgery;
Significant reduction in the infection incidence associated with permanent pacemaker implantation
Esophageal/gastroduodenal
Probable pathogens:enteric gram-negative bacilli, gram-positive cocci
Treatment (high-risk only, i.e. esophageal obstruction, decreased gastric acidity/gastrointestinal motility, morbid obesity)
cefazolin (Ancef, Defzol) (IV)
Biliary tract
Probable pathogens: enteric gram-negative bacilli, enterococci, clostridia
Treatment (high-risk only,i.e. age > 70, acute cholecystitis, non-functioning gallbladder, obstructive jaundice or common duct stones)
cefazolin (Ancef, Defzol) (IV)
Colorectal
Probable pathogens: enteric gram-negative bacilli, anaerobes, enterococci
Treatment:
Oral --neomycin + erythromycin base
Parenteral -- cefoxitin (Mefoxin) or cefotetan (Cefotan) Or
Parenteral-- cefazolin (Ancef, Defzol) + metronidazole (Flagyl)
Appendectomy, non-perforated
Probable pathogens: enteric gram-negative bacilli, anaerobes, enterococci
Treatment: cefoxitin (Mefoxin) Lorcet (hydrocodone/acetaminophen) fatigue and (IV)
Antibiotic prophylaxis:
recommended for esophageal surgery with obstruction -- obstruction increases infection risk
factors that promote high infection risk after gastroduodenal surgery:
reduced gastric acidity and gastrointestinal motility -- reduction may occur because of:
obstruction
hemorrhage
gastric ulcer
malignancy
treatment with H2 blocker {ranitidine (Zantac)} or proton pump, inhibitors {e.g. omeprazole (Prilosec)}
morbid obesity
Antibiotic prophylaxis not indicated for:
routine gastroesophageal endoscopy (may be used for high-risk patients undergoing esophageal dilatation or sclerotherapy of varicies)
Vaginal or abdominal hysterectomy
Probable pathogens: Enteric gram-negatives, anaerobes, enterococci, Group B strep
Treatment: cefazolin (Ancef, Defzol) or cefotetan (Cefotan) or cefoxitin (Mefoxin)(IV)
Cesarean section
Probable pathogens: Enteric gram-negatives, anaerobes, enterococci, Group B strep
Treatment: high-risk {active labor or premature membrane rupture};cefazolin (Ancef, Defzol) -- IV after cord clamping
Abortion
Probable pathogens: Enteric gram-negatives, anaerobes, enterococci, Group B strep
Treatment: first trimester, high-risk {patients with previous pelvic inflammatory disease, previous gonorrhea or multiple sex partners) -- aqueous penicillin V (Pen-Vee K, Veetids) or doxycycline (Vibramycin, Doryx)
Antibacterial prophylaxis:
reduces infection incidence following vaginal hysterectomy and abdominal hysterectomy (probably)
Perioperative/preoperative antibiotics: prevention of infection when given:
following cord clamping in emergency cesarean section
high-risk situations {active Labor, premature membrane rupture,after mid-trimester abortion}
Possibly substantial protective effect of perioperative antibiotics in all women undergoing therapeutic abortions
Probable pathogens: enteric gram-negative bacilli, enterococci
Treatment: high-risk only (urinate culture positive/unavailable; preoperative catheter, transrectal prostatic biopsy) --ciprofloxacin (Cipro) {PO or IV}
Incision through oral/pharyngeal mucosa.
Probable pathogens: Anaerobes, enteric gram-negative bacilli, Staphylococcus aureus
Treatment: clindamycin (Cleocin) + gentamicin (Garamycin)
reduce the high incidence of wound infection following head/neck operations which utilize incisions through oral or pharyngeal mucosal
Craniotomy
Probable pathogens: Staphylococcus aureus, Staphylococcus epidermidis
Treatment: cefazolin (Ancef, Defzol) or vancomycin (Vancocin) (IV)
Antibacterial prophylaxis
cerebrospinal fluid shunt: conflicting research results
Craniotomy: antistaphylococcal antibiotic -- reduced infection incidence
Spinal surgery: antibiotics not effective in reducing the already low postoperative infection rate following conventional lumbar discectomy.
Questionable effectiveness (not yet demonstrated in controlled clinical trials) for spinal fusion, prolonged spine surgery, or insertion of foreign material
Probable pathogens: Staphylococcus epidermidis, Staphylococcus aureus, streptococci, enteric gram-negative bacilli, Pseudomonas
Treatment: gentamicin (Garamycin), tobramycin (Nebcin), ciprofloxacin (Cipro), ofloxacin (Floxin), or neomycin-gramicidin-polymixin B; cefazolin (Ancef, Defzol)
Most ophthalmologist use antibiotic eyedrops for prophylaxis in view of the potential for extremely serious postoperative endophthalmitis.{limited data to support effectiveness of prophylactic antimicrobials}
No evidence for the rational basis for use of prophylactic antibiotics when procedures do not invade the globe
Total joint replacement, internal fracture fixation
Probable pathogens: Staphylococcus aureus, Staphylococcus epidermidis
Treatment: cefazolin (Ancef, Defzol) or vancomycin (Vancocin) (IV)
Rationale for Prophylaxis:
antistaphylococcal agents decrease incidence of early and late infection following joint replacement
decrease infection rate in compound/open fractures and when hip and other fractures are managed with internal fixation using nails, plates, screws, or wires
For diagnostic and operative arthroscopic surgery -- antibody prophylaxis is not justified
Probable pathogens: Staphylococcus aureus, Staphylococcus epidermidis, streptococci, enteric gram-negative bacilli
Treatment: cefazolin (Ancef, Defzol) or cefuroxime (Zinacef, Ceftin) or vancomycin (Vancocin)
Rationale for Prophylaxis:
commonly used for routine pulmonary surgery; limited research support
insertion of chest tubes following closed-tube thoracostomy following chest trauma: cephalosporin (multiple doses) can prevent infection
single preoperative cefazolin (Ancef, Defzol) dose (pulmonary resection): decrease in the incidence of wound infection -- no decrease in incidence of pneumonia or empyema
Arterial surgery (involving: a prosthesis, abdominal aorta, or groin incision)
Probable pathogen: Staphylococcus aureus, Staphylococcus epidermidis, enteric gram-negative bacilli
Treatment: cefazolin (Ancef, Defzol) or vancomycin (Vancocin)
A lower extremity amputation for ischemia
Probable pathogen: Staphylococcus aureus, Staphylococcus epidermidis, enteric gram-negative bacilli, clostridia
Treatment: cefazolin (Ancef, Defzol)--or cefoxitin (Mefoxin) for better anaerobic coverage--or vancomycin (Vancocin)
Rationale for prophylaxis:
Cephalosporin: reduced likelihood of postoperative infection incidences following arterial reconstructive surgery on the abdominal aorta, vascular limb operations involving groin incisions, and lower extremity amputation for ischemia
Recommended: for any vascular prosthetic material implantation (e.g. grafts supporting hemodialysis)
Not indicated: carotid endarterectomy or brachial artery repair (assuming no prosthetic material involved)
The Medical Letter on Drugs and Therapeutics, "Antimicrobial Prophylaxis in Surgery", vol. 41 (issue 1060), August 27, 1999