Peptic Ulcer Disease

Table of Contents
Overview Classification of peptic ulcers Gastric Physiology Gastric Mucosa-Acid Secretion Oxidative phosphorylation Regulation of Gastric Acid Secretion Gastrin-stimulatory Vagal effects-stimulatory Role of histamine Parietal Cell Membrane Receptors Physiological Stumulants of Gastric Acid Secretion Food Cephalic Gastric Intestinal Physiological Inhibition of Gastric Acid Secretion Factors Somatostatin Effects Role of pepsin in peptic ulcer disease Pathogenic Factors Helicobacter Pylorii H. Pylorii Management: Clinical Efficacy Other Pathogenic Factors	Drug Treatment Helicobacter pylorii Bismuth Triple Therapy Drawbacks of Triple Therapy Antacids H₂ Receptor Antagonists Anticholinergic Drugs Coating Agents Sucralfate Colloidal Bismuth Prostaglandins Proton Pump Inhibitors Important GI Drugs: Listing Other GI Drugs Gastrokinetic Agents Antacids (used as preoperative medication) Antiemetic Drugs

Benign Ulcer

"Benign chronic gastric ulcer: note sharp margins, flat relatively clean ulcer base and folds that radiate from the ulcer margin, location on the lesser curvature in the antrum at the fundopyloric junctional mucosa (precepitous proximal and sloping distal border not clearly seen)." Courtesy of the University of Texas Health Science Center

Benign Ulcer

"Benign chronic gastric ulcer: note sharp margins, flat relatively clean ulcer base and folds that radiate from the ulcer margin, location on the lesser curvature in the antrum at the fundopyloric junctional mucosa (precepitous proximal and sloping distal border not clearly seen)."
Courtesy of the University of Texas Health Science Center