Anesthesia Pharmacology Chapter 4:  Physics and Anesthesiology

 
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6Blood: gas partition coefficients

Sevoflurane (Sevorane, Ultane)

Desflurane (Suprane)

Isoflurane (Forane)

Enflurane (Ethrane)

Halothane (Fluothane)

Nitrous oxide

0.65

0.42

1.46

1.9

2.4

0.46

 

Factors that Increase or Decrease the Rate of Rise of FA/FI

Increase Rate of Rise of FA/FI

Decrease Rate of Rise of FA/FI

Comment

low B

high B

As the blood solubility decreases, the rate of rise in FA/FI increases.

low Q

high Q

The lower the cardiac output, the faster the rate of rise in FA/FI 

high A

low A

The higher the minute ventilation, the faster the rate of rise in FA/FI 

high (PA - PV)

low (PA - PV)

"At the beginning of induction, PV is zero but increases rapidly (thus [PA-PV] falls rapidly) and FA/FI increase rapidly.  Later during induction and maintenance, PV rises more slowly so FA/FI rises more slowly."

: blood solubility; Q = cardiac output; A = minute ventilation; PA , PV pulmonary alveolar & venous blood partial pressure

 
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