Anesthesia Pharmacology Practice Questions: Local Anesthetics

Local anesthetics prevent nerve conduction principally by affecting this ion-channel:
1. Potassium
2. Sodium
3. Chloride
4. Calcium
These nerve fibers appear more sensitive to the action of local anesthetics with respect to reduced action potential propagation.
1. Large-diameter, rapidly conducting fibers
2. Small-diameter myelinated slowly conducting fibers
3. Both Fiber types are affected equally
Autonomic nerve fibers, small myelinated fibers mediating pain and temperature sensations and small unmyelinated C fibers transmitting pain sensations are blocked before larger myelinated fibers.
1. True
2. False
Local anesthetics are:
1. Weak acids
2. Weak bases
3. Neither
This form of the local anesthetic preferentially interacts with sodium channels:
1. The unprotonated form (uncharged)
2. The protonated form (cationic, charged)
Purpose(s) of adding epinephrine to the local anesthetic solution:
1. Increasing the duration of the local anesthetic effect through vasoconstriction.
2. Maintaining a similar rate of local anesthetic absorption into the general circulation and the rate of metabolism of the drug, thus reducing the likelihood of systemic toxicity
3. Both
4. Neither
Administration of this/these local anesthetic(s) cause vasoconstriction:
1. Bupivacaine
2. Ropivacaine
3. Both
4. Neither
Local anesthetics upon reaching the systemic circulation may result CNS effects including:
1. Initial CNS depression
2. Tremor
3. Clonic convulsions
4. A & B
5. B & C
6. A, B & C
Local anesthetic effect(s) include(s):
1. Reduced myocardial conduction velocity
2. Reduced force of contraction
3. Both
4. Neither
Which one(s) of the following local anesthetics may be administered to manage cardiac arrhythmias?
1. Procainamide
2. Lidocaine
3. Both
4. Neither