Anesthesia Pharmacology Practice Questions: Opioid Analgesics

Levorphanol is an opioid agonists classified as part of the morphinan series.
1. True
2. False
The D-isomer of levorphanol inhibits NMDA receptors while activating mu-type opioid receptors.
1. True
2. False
Other drugs in the same class as levorphanol include:
1. Butorphanol (Stadol)
2. Nalbuphene (Nubain)
3. Both
4. Neither
Pharmacological actions associated with levorphenol administration appear very similar to those of morphine.
1. True
2. False
Meperidine, a potent mu receptor opioid agonist, produces both substantial analgesic effects as well as respiratory depression.
1. True
2. False
Choose the correct statement(s) concerning meperidine pharmacology:
1. The meperidine metabolite, normeperidineis biologically inactive.
2. Meperidine exhibits local anesthetic properties which can be observed following epidural administration.
3. Meperidine administration may result in increased cerebral blood flow with increased cerebrospinal fluid pressure secondary to drug-induced respiratory depression leading to increased carbon dioxide levels.
4. A & B
5. B & C
6. A, B & C
IV administration of meperidine is likely to produce a notable elevation in heart rate.
1. True
2. False
Principal clinical use(s) for meperidine include/includes:
1. Analgesia
2. Cough
3. Control of diarrhea
4. A & B
5. A & C
6. A, B & C
Chlorpromazine and tricyclic antidepressant medications (first-generation agents) are examples of drugs that increase meperidine induced respiratory depression.
1. True
2. False
Because meperidine crosses the placental barrier only at high doses, reasonable analgesic doses do not affect the percentage of babies exhibiting delayed respiration or reduced respiratory minute volume.
1. True
2. False