Anesthesia Pharmacology:  Pulmonary Pharmacology

Section Table of Contents

Site Table of Contents

Previous Page Next Page

1Mechanisms involved in pathology associated with asthma

  • Bradykinin

  • Histamine (as the chloride)

 

Prostaglandins in Asthma

  • Prostaglandin F2

  • Prostaglandin D2

 

Arachidonic Acid Pathway (Leukotriene, Prostaglandin, Thromboxane Synthesis

 

Leukotrienes

  • Leukotriene C4

  • Leukotriene D4

  • Leukotriene E4

  • Leukotriene B4

 

Platelet Activating Factor

  • Platelet Activating Factor, 1-alkyl, 2-acetyl phosphatidylcholine

 

6Structure of the CC-chemokine, RANTES

  • 6"The beta-chemokines include RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted) as well as macrophage inflammatory protein-1 (MIP-1) alpha and beta, and interleukin-8...."

  • 6"Here, the structure of RANTES is shown (Chung et al. Biochemistry 34:9307, 1995). It is a small (8 kDa) dimeric protein that is highly basic (pI 9.5) and which is made up of two identical subunits of 68 amino acids each. The two monomers are shown here"

 

 

7Human Granulocyte-Macrophage Colony-Stimulating Factor

  • "Granulocyte-macrophage colony stimulating factor (GM-CSF) stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, erythrocytes, and eosinophils

  • The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhGM- CSF is a four a-helix bundle, which represents approximately 42% of the structure. The helices are arranged in a left-handed antiparallel bundle with two overhand connections. Within the connections is a two-stranded antiparallel b-sheet. In this ribbon drawing, the N terminus is the upper right-hand corner."--7Ealick SE

  • Ribbon Form: Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.

  • Experimental method:  X-ray Diffraction; Protein Data Bank

 

Relationship between Mediators and Response Time Course: Diagram from Reference 2

Previous Page Next Page

Section Table of Contents

Site Table of Contents

This Web-based pharmacology and disease-based integrated teaching site is based on reference materials, that are believed reliable and consistent with standards accepted at the time of development. Possibility of human error and on-going research and development in medical sciences do not allow assurance that the information contained herein is in every respect accurate or complete. Users should confirm the information contained herein with other sources. This site should only be considered as a teaching aid for undergraduate and graduate biomedical education and is intended only as a teaching site. Information contained here should not be used for patient management and should not be used as a substitute for consultation with practicing medical professionals. Users of this website should check the product information sheet included in the package of any drug they plan to administer to be certain that the information contained in this site is accurate and that changes have not been made in the recommended dose or in the contraindications for administration.  Advertisements that appear on this site are not reviewed for content accuracy and it is the responsibility of users of this website to make individual assessments concerning this information.  Medical or other information  thus obtained should not be used as a substitute for consultation with practicing medical or scientific or other professionals.