Medical Pharmacology Chapter 25: Pulmonary Pharmacology Practice Questions

Corticosteroids:
1. Reduce corticotropin secretion
2. Reduce cortisol secretion
3. Both
4. Neither
Corticosteroid administration results in a negative-feedback loop affecting the pituitary gland.
1. True
2. False
Corticosteroid treatment of short-duration is likely to significantly suppress the hypothalamic-pituitary-adrenal (HPA) axis.
1. True
2. False
Hypothalamic-pituitary-adrenal axis suppression (HPA suppression) is not observed when corticosteroid route of administration is by inhalation.
1. True
2. False
Following prolonged steroid treatment (oral therapy):
1. Steroid doses should be reduced gradually (tapering).
2. Steroid withdrawal syndrome can include musculoskeletal pain, fever, and lassitude.
3. Both
4. Neither
In elderly patients: consequence/consequences of high-dose inhaled steroids include/includes:
1. Dermal thinning
2. Increase skin capillary fragility.
3. Both
4. Neither
Inhaled corticosteroids: local side effects due to increased steroid accumulation in the oropharynx
1. Hoarseness
2. Vocal weakness (dysphonia)
3. Both
4. Neither
Higher doses of inhaled corticosteroids may increase pneumonia risk in COPD patients.
1. True
2. False
Compared to beclomethasone which one/ones of the following exhibit lower oral bioavailability due to increased first-past liver metabolism?
1. Budesonide
2. Mometasone
3. Ciclesonide
4. A & B
5. B & C
6. A, B & C
Beclomethasone dipropionate administration is associated with fewer systemic side effects compared to fluticasone or budesonide at high doses (>1000 ug).
1. True
2. False