Nursing Pharmacology Chapter 8: Antiarrhythmic Agents
Electrophysiology and Cardiac Arrhythmias
Normal rate: 60-100 beats per minute
Impulse Propagation: sinoatrial node to the atrioventricular (AV node) to the His-Purkinje followed by distribution throughout the ventricle
Normal AV nodal delay (0.15 seconds) which is sufficient to allow atrial ejection of blood into the ventricles
Definition: arrhythmia: a cardiac depolarization different from above sequence.
Abnormal origination (not SA nodal)
Abnormal conduction characteristics
Hondeghem, L.M. and Roden, D.M., "Agents Used in Cardiac Arrhythmias", in Basic and Clinical Pharmacology, Katzung, B.G., editor, Appleton & Lange, 1998, pp 216-241.