Anesthesia Pharmacology: Gastrointestinal Drugs
Pharmacological Management of Ulcer Disease
Other GI Drugs
Peptic ulcer: stomach or duodenal mucosal lesion WITH acid and pepsin playing major pathogenic roles.
Major causative factor: bacterium Helicobacter pylori
Helicobacter pylori is a risk factor for:
Certain types of gastric lymphoma
Zollinger-Ellison syndrome (causative agent-gastrin-secreting islet cell tumor (gastrinoma)) is considered a form of peptic ulcer
Caused by an imbalance between aggressive factors (mainly gastric acid and pepsin) and protective factors (mucosal defenses).
Friedman, L. S. and Peterson, W.L. Peptic Ulcer and Related Disorders In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., and Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp. 1597-1616.
This Web-based pharmacology and disease-based integrated teaching site is based on reference materials, that are believed reliable and consistent with standards accepted at the time of development. Possibility of human error and on-going research and development in medical sciences do not allow assurance that the information contained herein is in every respect accurate or complete. Users should confirm the information contained herein with other sources. This site should only be considered as a teaching aid for undergraduate and graduate biomedical education and is intended only as a teaching site. Information contained here should not be used for patient management and should not be used as a substitute for consultation with practicing medical professionals. Users of this website should check the product information sheet included in the package of any drug they plan to administer to be certain that the information contained in this site is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. Advertisements that appear on this site are not reviewed for content accuracy and it is the responsibility of users of this website to make individual assessments concerning this information. Medical or other information thus obtained should not be used as a substitute for consultation with practicing medical or scientific or other professionals.