Anesthesia Pharmacology:  Physics and  Chemistry for Anesthesiology

Hemoglobin Protein Dynamics

 

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Oxy to Deoxyhemoglobin Transition: Molecular Motion

 

 

Histidine Structure

Central Cavity in deoxyhemoglobin which defines the DPG binding location

 

Note the reduced central cavity size in oxyhemoglobin with attendant prevention of DPG binding

 

(2,3)-DPG

 

 

 

 

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